Abstract | BACKGROUND/AIMS: METHODOLOGY: DPI was measured in 18 patients with colorectal cancer liver metastases and 18 control subjects. Sixteen patients were underwent contrast-enhanced ultrasonography (CEUS). RESULTS: patients with liver metastases had significantly greater DPI than control group (0.39 +/- 0.10 vs. 0.19 +/- 0.07, p < 0.05). Sixteen liver metastasis lesions underwent a rapid wash-out of contrast agent during the portal venous phase followed by a complete wash-out of SonoVue during the sinusoidal phase and were differentiated as "fast-in and fast-out" contrast enhancement patter. Another 3 lesions which were not found by baseline ultrasonography were detected to be enhancement defects at sinusoidal phases by CEUS. CONCLUSIONS: DPI is a sensitive index in detection of colorectal liver metastases; if used combined with contrast agent, much more occult liver metastasis would be detected by ultrasonography.
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Authors | Litao Ruan, Shengzhi Wang, Jin Zhang, Hong Ai, Qiaoling Zhao, Jinru Yang, Wei Wei |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2014 Jan-Feb
Vol. 61
Issue 129
Pg. 37-41
ISSN: 0172-6390 [Print] Greece |
PMID | 24895790
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contrast Media
- Phospholipids
- contrast agent BR1
- Sulfur Hexafluoride
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Topics |
- Adult
- Aged
- Case-Control Studies
- Colorectal Neoplasms
(pathology)
- Contrast Media
(pharmacokinetics)
- Female
- Humans
- Liver Neoplasms
(diagnostic imaging, secondary)
- Male
- Middle Aged
- Phospholipids
(pharmacokinetics)
- Sensitivity and Specificity
- Sulfur Hexafluoride
(pharmacokinetics)
- Ultrasonography, Doppler
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