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Doppler perfusion index and contrast-enhanced ultrasound in patients with colorectal cancer liver metastases.

AbstractBACKGROUND/AIMS:
To assess the value of the Doppler perfusion index (DPI) and contrast agent for the detection of liver metastases in patients with colorectal cancer.
METHODOLOGY:
DPI was measured in 18 patients with colorectal cancer liver metastases and 18 control subjects. Sixteen patients were underwent contrast-enhanced ultrasonography (CEUS).
RESULTS:
patients with liver metastases had significantly greater DPI than control group (0.39 +/- 0.10 vs. 0.19 +/- 0.07, p < 0.05). Sixteen liver metastasis lesions underwent a rapid wash-out of contrast agent during the portal venous phase followed by a complete wash-out of SonoVue during the sinusoidal phase and were differentiated as "fast-in and fast-out" contrast enhancement patter. Another 3 lesions which were not found by baseline ultrasonography were detected to be enhancement defects at sinusoidal phases by CEUS.
CONCLUSIONS:
DPI is a sensitive index in detection of colorectal liver metastases; if used combined with contrast agent, much more occult liver metastasis would be detected by ultrasonography.
AuthorsLitao Ruan, Shengzhi Wang, Jin Zhang, Hong Ai, Qiaoling Zhao, Jinru Yang, Wei Wei
JournalHepato-gastroenterology (Hepatogastroenterology) 2014 Jan-Feb Vol. 61 Issue 129 Pg. 37-41 ISSN: 0172-6390 [Print] Greece
PMID24895790 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Contrast Media
  • Phospholipids
  • contrast agent BR1
  • Sulfur Hexafluoride
Topics
  • Adult
  • Aged
  • Case-Control Studies
  • Colorectal Neoplasms (pathology)
  • Contrast Media (pharmacokinetics)
  • Female
  • Humans
  • Liver Neoplasms (diagnostic imaging, secondary)
  • Male
  • Middle Aged
  • Phospholipids (pharmacokinetics)
  • Sensitivity and Specificity
  • Sulfur Hexafluoride (pharmacokinetics)
  • Ultrasonography, Doppler

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