Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition.

Abstract

A 16-year-old perioperative paediatric patient presented with refractory lactic acidosis and multiorgan failure due to thiamine-deficient total parenteral nutrition during a recent national multivitamin shortage. Urgent empiric administration of intravenous thiamine resulted in prompt recovery from this life-threatening condition. Despite readily available treatment, a high index of suspicion is required to prevent cardiovascular collapse and mortality.

• Authors: Musaab Ramsi, Claire Mowbray, Gary Hartman, Natalie Pageler
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2014 (Jun 03 2014) ISSN: 1757-790X [Electronic] England
• PMID: 24895398 (Publication Type: Case Reports, Journal Article)
• Copyright: 2014 BMJ Publishing Group Ltd.

Chemical References

• Lactic Acid

Topics

• Acidosis, Lactic (blood, diagnosis, etiology)
• Adolescent
• Diagnosis, Differential
• Humans
• Hydrogen-Ion Concentration
• Lactic Acid (blood)
• Male
• Multiple Organ Failure (diagnosis, etiology)
• Parenteral Nutrition, Total
• Thiamine Deficiency (complications, therapy)