An unusual case of Acanthamoeba Polyphaga and Pseudomonas Aeruginosa keratitis.

Abstract

A 56-year-old woman with a history of disposable soft contact lens wear was referred to our university eye center for a corneal ulcer. Based on the microbial culture, the initial diagnosis was bacterial keratitis, which was unresponsive to topical fortified antibiotics. The patient was then examined using in vivo confocal microscopy, which revealed Acanthamoeba infection. This case emphasizes the need to suspect Acanthamoeba infection in soft contact lens wearers who present with progressive ulcerative keratitis or progressively worsening corneal ulcers that are not responsive to the usual antimicrobial therapy. It is also important to consider the possibility of a coinfection with bacterial and Acanthamoeba species.

VIRTUAL SLIDES:

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• Authors: Jiaxu Hong, Jian Ji, Jianjiang Xu, Wenjun Cao, Zuguo Liu, Xinghuai Sun
• Journal: Diagnostic pathology (Diagn Pathol) Vol. 9 Pg. 105 (Jun 03 2014) ISSN: 1746-1596 [Electronic] England
• PMID: 24894486 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents

Topics

• Anti-Infective Agents (therapeutic use)
• Coinfection
• Contact Lenses, Hydrophilic (microbiology, virology)
• Corneal Ulcer (diagnosis, drug therapy, microbiology, virology)
• Eye Infections, Bacterial (diagnosis, drug therapy, microbiology)
• Eye Infections, Viral (diagnosis, drug therapy, virology)
• Female
• Humans
• Middle Aged
• Mimiviridae (isolation & purification)
• Pseudomonas Infections (diagnosis, drug therapy, microbiology)
• Pseudomonas aeruginosa (isolation & purification)