Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients.

Abstract

BACKGROUND:

Hyaluronidase (Hylase Dessau(®)) is a hyaluronic acid-metabolizing enzyme, which has been shown to loosen the extracellular matrix, thereby improving the diffusion of local anesthetics. Lower eyelid edema is a common post-interventional complication of cosmetic procedures performed in the lid region, such as the injection of hyaluronic acid fillers for tear-trough augmentation. The purpose of this study was to validate the efficacy of hyaluronidase in the management of lower eyelid edema.

METHODS:

We performed a retrospective analysis with 20 patients with lower eyelid edema. Most patients (n = 14) presented with edema following hyaluronic acid injection (tear-trough augmentation), whereas the minority (n = 6) were treated due to idiopathic edema (malar edema or malar mounds). Patients were treated by local infiltration of approximately 0.2 ml to 0.5 ml of hyaluronidase (Hylase Dessau(®) 20 IU to 75 IU) per eyelid. Photographs were taken prior to and seven days after infiltration.

RESULTS:

Hyaluronidase was found to reduce effectively and rapidly or resolve eyelid edema after a single injection. No relevant adverse effects were observed. However, it must be noted that a hyaluronidase injection may also dissolve injected hyaluronic acid fillers and may therefore negatively affect tear-trough augmentations. While the effects of a treatment for edema due to tear-trough augmentation were permanent, malar edema and malar mounds reoccurred within two to three weeks.

CONCLUSION:

The infiltration of hyaluronidase is rapid, safe and currently the only effective option for the management of eyelid edema. No relevant adverse effects were observed.

• Authors: Said Hilton, Holger Schrumpf, Bettina Alexandra Buhren, Edwin Bölke, Peter Arne Gerber
• Journal: European journal of medical research (Eur J Med Res) Vol. 19 Pg. 30 (May 28 2014) ISSN: 2047-783X [Electronic] England
• PMID: 24886711 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hyaluronic Acid
• Hyaluronoglucosaminidase

Topics

• Adult
• Aged
• Cosmetic Techniques
• Edema (drug therapy, etiology)
• Eyelid Diseases (drug therapy, etiology)
• Eyelids (surgery)
• Female
• Humans
• Hyaluronic Acid (adverse effects)
• Hyaluronoglucosaminidase (therapeutic use)
• Male
• Middle Aged
• Retrospective Studies