Whole-body muscle MRI to detect myopathies in non-extrapyramidal bent spine syndrome.

Abstract

OBJECTIVE:

Bent spine syndrome (BSS), defined as an abnormal forward flexion of the trunk resolving in supine position, is usually related to parkinsonism, but can also be encountered in myopathies. This study evaluates whole-body muscle MRI (WB-mMRI) as a tool for detecting underlying myopathy in non-extrapyramidal BSS.

MATERIALS AND METHODS:

Forty-three patients (90 % women; 53-86 years old) with a non-extrapyramidal BSS were prospectively included. All underwent a 1.5-T WB-mMRI and a nerve conduction study. Muscle biopsy was performed if a myopathy could not be eliminated based on clinical examination and all tests. Systematic MRI interpretation focused on peripheral and axial muscle injury; spinal posture and incidental findings were also reported.

RESULTS:

WB-mMRI was completed for all patients, with 13 muscle biopsies ultimately needed and myopathy revealed as the final etiological diagnosis in five cases (12 %). All biopsy-proven myopathies were detected by the WB-mMRI. Relevant incidental MRI findings were made in seven patients.

CONCLUSIONS:

This study supports WB-mMRI as a sensitive and feasible tool for detecting myopathy in BSS patients. Associated with electroneuromyography, it can better indicate when a muscle biopsy is needed and guide it when required. Rigorous radiological interpretation is mandatory, so as not to miss incidental findings of clinical consequence.

• Authors: Mickaël Ohana, Marie-Christine Durand, Catherine Marty, Jean-Philippe Lazareth, Thierry Maisonobe, Dominique Mompoint, Robert-Yves Carlier
• Journal: Skeletal radiology (Skeletal Radiol) Vol. 43 Issue 8 Pg. 1113-22 (Aug 2014) ISSN: 1432-2161 [Electronic] Germany
• PMID: 24878839 (Publication Type: Journal Article)

Topics

• Aged
• Aged, 80 and over
• Biopsy (methods)
• Feasibility Studies
• Female
• Humans
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Muscle, Skeletal (pathology)
• Muscular Atrophy, Spinal (complications, pathology)
• Muscular Diseases (complications, diagnosis, pathology)
• Observer Variation
• Prospective Studies
• Sensitivity and Specificity
• Spinal Curvatures (complications, pathology)
• Whole Body Imaging (methods)