[Nilotinib in patients with chronic myeloid leukemia without response to imatinib].

Abstract

BACKGROUND:

Resistance and intolerance to imatinib in patients with chronic myeloid leukemia requires alternative therapies. Nilotinib provides a choice as a second-line treatment. The objective of this report was to show the results of a group of patients with chronic myeloid leukemia who received nilotinib as a second-line treatment.

METHODS:

The medical records of 16 patients of both sexes, of any age, diagnosed with chronic myeloid leukemia, who received nilotinib as a second-line treatment, were reviewed. All of them had received imatinib prior as first-line treatment; the causes to switch to nilotinib were intolerance, resistance and clinical progression of leukemia.

RESULTS:

The sample was of 16 patients, who achieved at least a hematologic response; 10 were males (62.5%). The age range was 24 to 75 years. Two patients received nilotinib due to intolerance to imatinib; seven due to resistance to imatinib and seven due to lack of response. There was response in the two patients who received nilotinib due to intolerance. One patient died five months after starting nilotinib due to progression of leukemia; four patients achieved major molecular response, two patients had reduced expression of BCR-ABL gene. Six patients continued with high expression of BCR-ABL gene; two of them carrying M244V mutation, and one with a complex karyotype with numerical and structural alterations.

CONCLUSIONS:

Nilotinib is an option for patients with intolerance or resistance to imatinib.

• Authors: Enrique Báez-de la Fuente, Baltazar Arellano-Severiano
• Journal: Revista medica del Instituto Mexicano del Seguro Social (Rev Med Inst Mex Seguro Soc) 2014 May-Jun Vol. 52 Issue 3 Pg. 330-3 ISSN: 2448-5667 [Electronic] Mexico
• Vernacular Title: Nilotinib en pacientes con leucemia mieloide crónica con falla a imatinib.
• PMID: 24878095 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Benzamides
• Piperazines
• Pyrimidines
• Imatinib Mesylate
• nilotinib

Topics

• Adult
• Aged
• Antineoplastic Agents (therapeutic use)
• Benzamides (therapeutic use)
• Female
• Humans
• Imatinib Mesylate
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (drug therapy)
• Male
• Middle Aged
• Piperazines (therapeutic use)
• Pyrimidines (therapeutic use)
• Treatment Failure
• Young Adult