FOXP3 transcription factor: a candidate marker for susceptibility and prognosis in triple negative breast cancer.

Abstract	Triple negative breast cancer (TNBC) is a relevant subgroup of neoplasia which presents negative phenotype of estrogen and progesterone receptors and has no overexpression of the human epidermal growth factor 2 (HER2). FOXP3 (forkhead transcription factor 3) is a marker of regulatory T cells (Tregs), whose expression may be increased in tumor cells. This study aimed to investigate a polymorphism (rs3761548) and the protein expression of FOXP3 for a possible involvement in TNBC susceptibility and prognosis. Genetic polymorphism was evaluated in 50 patients and in 115 controls by allele-specific PCR (polymerase chain reaction). Protein expression was evaluated in 38 patients by immunohistochemistry. It was observed a positive association for homozygous AA (OR = 3.78; 95% CI = 1.02-14.06) in relation to TNBC susceptibility. Most of the patients (83%) showed a strong staining for FOXP3 protein in the tumor cells. In relation to FOXP3-positive infiltrate, 47% and 58% of patients had a moderate or intense intratumoral and peritumoral mononuclear infiltrate cells, respectively. Tumor size was positively correlated to intratumoral FOXP3-positive infiltrate (P = 0.026). In conclusion, since FOXP3 was positively associated with TNBC susceptibility and prognosis, it seems to be a promising candidate for further investigation in larger TNBC samples.
Authors	Leandra Fiori Lopes, Roberta Losi Guembarovski, Alda Losi Guembarovski, Marina Okuyama Kishima, Clodoaldo Zago Campos, Julie Massayo Maeda Oda, Carolina Batista Ariza, Karen Brajão de Oliveira, Sueli Donizete Borelli, Maria Angelica Ehara Watanabe
Journal	BioMed research international (Biomed Res Int) Vol. 2014 Pg. 341654 ( 2014) ISSN: 2314-6141 [Electronic] United States
PMID	24877082 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Biomarkers, Tumor FOXP3 protein, human Forkhead Transcription Factors
Topics	Adult Biomarkers, Tumor (biosynthesis, genetics) Breast Neoplasms (genetics, metabolism, pathology) Female Forkhead Transcription Factors (biosynthesis, genetics) Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Humans Middle Aged Polymorphism, Genetic

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