High frequency of diabetes and impaired fasting glucose in patients with glucose-6-phosphate dehydrogenase deficiency in the Western brazilian Amazon.

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, and it has a significant prevalence in the male population (X chromosome linked). The purpose of this study was to estimate the frequency of impaired fasting glucose and diabetes among G6PD-deficient persons in Manaus, Brazil, an area in the Western Brazilian Amazon to which malaria is endemic. Glucose-6-phosphate dehydrogenase-deficient males had more impaired fasting glucose and diabetes. This feature could be used as a screening tool for G6PD-deficient persons who are unable to use primaquine for the radical cure of Plasmodium vivax malaria.

• Authors: Marli S Santana, Wuelton M Monteiro, Mônica R F Costa, Vanderson S Sampaio, Marcelo A M Brito, Marcus V G Lacerda, Maria G C Alecrim
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 91 Issue 1 Pg. 74-6 (Jul 2014) ISSN: 1476-1645 [Electronic] United States
• PMID: 24865682 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The American Society of Tropical Medicine and Hygiene.

Chemical References

• Antimalarials
• Blood Glucose
• Primaquine

Topics

• Adolescent
• Adult
• Aged
• Antimalarials
• Blood Glucose (metabolism)
• Brazil (epidemiology)
• Child
• Contraindications
• Diabetes Complications
• Diabetes Mellitus (drug therapy, epidemiology, parasitology)
• Fasting
• Glucosephosphate Dehydrogenase Deficiency (complications, drug therapy, epidemiology, parasitology)
• Humans
• Malaria, Vivax (complications, drug therapy, epidemiology, parasitology)
• Male
• Middle Aged
• Plasmodium vivax
• Prevalence
• Primaquine