Age related
cataract is the leading cause of
blindness associated with accumulation of oxidative stress in the eye lens. The present investigation reveals the rational of the beneficial effects of the natural compound
C-phycocyanin (C-PC) is beneficial when administered to rat pups to protect against the secondary effects of
sodium selenite induced cataractogenesis. A single subcutaneous dose of
sodium selenite (19 μmol/kg
body weight) on the 10th day of postpartum is adequate to induce
cataract in rat pups. Serum biochemical parameters, such as the level of
electrolytes, mean activities of
anti-oxidant enzymes i.e.
superoxide dismutase,
catalase and
reduced glutathione were observed to be significantly altered during
selenite induced cataractogenic process. Histopathological examination revealed signs of degradation of normal cell architecture in the liver, kidney and eye lens. Interestingly, the deleterious effects of
sodium selenite toxicity were restored with the simultaneous treatment with C-PC. The results suggest that an administration of 200 mg/kg
body weight of C-PC has the ability to prevent/alter the secondary changes reflected in the serum biochemical and histological modifications in rats exposed to
sodium selenite. These results
complement the beneficial role of C-PC of cyanobacterial origin as a efficacious anti-cataractogenic agent against
sodium selenite toxicity.