Acute hand ischemia after unintentional intraarterial injection of drugs: is catheter-directed thrombolysis useful?

Abstract

Unintentional intraarterial injections are rare but may have devastating consequences. No consensus on treatment has been established owing to the wide variety of possible injected substances, incomplete understanding of the underlying pathophysiology, and the absence of case-controlled, prospective human studies. The aim of the present study and literature review was to evaluate the benefit of intraarterial thrombolysis combined with systemic anticoagulation therapy when an artery of the upper extremity is accidentally punctured and ischemia of the hand ensues.

• Authors: Romain Breguet, Sylvain Terraz, Marc Righini, Dominique Didier
• Journal: Journal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 25 Issue 6 Pg. 963-8 (Jun 2014) ISSN: 1535-7732 [Electronic] United States
• PMID: 24857945 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2014 SIR. Published by Elsevier Inc. All rights reserved.

Chemical References

• Fibrinolytic Agents
• Recombinant Proteins
• Tissue Plasminogen Activator

Topics

• Acute Disease
• Adult
• Aged, 80 and over
• Angiography, Digital Subtraction
• Angioplasty, Balloon
• Fibrinolytic Agents (administration & dosage)
• Hand (blood supply)
• Humans
• Iatrogenic Disease
• Injections, Intra-Arterial (adverse effects)
• Ischemia (diagnosis, drug therapy, etiology)
• Male
• Recombinant Proteins (administration & dosage)
• Retrospective Studies
• Substance Abuse, Intravenous (complications)
• Thrombolytic Therapy
• Thrombosis (diagnosis, etiology, therapy)
• Tissue Plasminogen Activator (administration & dosage)
• Treatment Outcome
• Young Adult