Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer.

Abstract

BACKGROUND:

Recently, fibroblast growth factor receptor 1 (FGFR1) was discovered in squamous cell carcinomas (SCC) of the lung with FGFR1 amplification described as a promising predictive marker for anti-FGFR inhibitor treatment. Only few data are available regarding prevalence, prognostic significance and clinico-pathological characteristics of FGFR1-amplified and early-stage non-small cell lung carcinomas (NSCLC). We therefore investigated the FGFR1 gene status in a large number of well-characterised early-stage NSCLC.

METHODS:

FGFR1 gene status was evaluated using a commercially available fluorescent in situ hybridisation (FISH) probe on a tissue microarray (TMA). This TMA harbours 329 resected, formalin-fixed and paraffin-embedded, nodal-negative NSCLC with a UICC stage I-II. The FISH results were correlated with clinico-pathological features and overall survival (OS).

RESULTS:

The prevalence of an FGFR1 amplification was 12.5% (41/329) and was significantly (P<0.0001) higher in squamous cell carcinoma (SCC) (20.7%) than in adenocarcinoma (2.2%) and large cell carcinoma (13%). Multivariate analysis revealed significantly (P=0.0367) worse 5-year OS in patients with an FGFR1-amplified NSCLC.

CONCLUSIONS:

FGFR1 amplification is common in early-stage SCC of the lung and is an independent and adverse prognostic marker. Its potential role as a predictive marker for targeted therapies or adjuvant treatment needs further investigation.

• Authors: N Cihoric, S Savic, S Schneider, I Ackermann, M Bichsel-Naef, R A Schmid, D Lardinois, M Gugger, L Bubendorf, I Zlobec, C Tapia
• Journal: British journal of cancer (Br J Cancer) Vol. 110 Issue 12 Pg. 2914-22 (Jun 10 2014) ISSN: 1532-1827 [Electronic] England
• PMID: 24853178 (Publication Type: Journal Article)

Chemical References

• FGFR1 protein, human
• Receptor, Fibroblast Growth Factor, Type 1

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Non-Small-Cell Lung (genetics, mortality)
• Carcinoma, Squamous Cell (genetics, mortality)
• Disease-Free Survival
• Female
• Gene Amplification
• Humans
• In Situ Hybridization, Fluorescence
• Lung Neoplasms (genetics, mortality)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (genetics)
• Receptor, Fibroblast Growth Factor, Type 1 (genetics)
• Tissue Array Analysis