Abstract |
Whole-genome sequencing was used to compare longitudinal isolates of Staphylococcus aureus that developed resistance to oxacillin (MIC up to 16 μg/ml). The mecA gene was absent. A novel 5-bp TATCC frameshift insertion in a gene encoding an ABC transporter similar to that of the teichoic acid translocation ATP- binding protein TagH and a 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacillin-resistant isolates.
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Authors | Eileen M Burd, Mohammad Tauqeer Alam, Karla D Passalacqua, Ameeta S Kalokhe, Molly E Eaton, Sarah W Satola, Colleen S Kraft, Timothy D Read |
Journal | Journal of clinical microbiology
(J Clin Microbiol)
Vol. 52
Issue 8
Pg. 3114-7
(Aug 2014)
ISSN: 1098-660X [Electronic] United States |
PMID | 24850355
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2014, American Society for Microbiology. All Rights Reserved. |
Chemical References |
- ATP-Binding Cassette Transporters
- Anti-Bacterial Agents
- DNA, Bacterial
- Oxacillin
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Topics |
- ATP-Binding Cassette Transporters
(genetics)
- Aged, 80 and over
- Anti-Bacterial Agents
(pharmacology)
- Bacteremia
(microbiology)
- DNA, Bacterial
(chemistry, genetics)
- Drug Resistance, Bacterial
- Frameshift Mutation
- Genome, Bacterial
- Humans
- Longitudinal Studies
- Male
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutagenesis, Insertional
- Oxacillin
(pharmacology)
- Recurrence
- Sequence Analysis, DNA
- Staphylococcal Infections
(microbiology)
- Staphylococcus aureus
(drug effects, isolation & purification)
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