Abstract | OBJECTIVES: METHODS: We examined the association of these genes with key endophenotypes of SSD - phonological memory measured through multisyllabic and nonword repetition, vocabulary measured using the Expressive One Word Picture Vocabulary Test and Peabody Picture Vocabulary Test, and reading decoding measured using the Woodcock Reading Mastery Tests Revised - as well as with the clinical phenotype of SSD. We genotyped tag single nucleotide polymorphisms in these genes and examined 498 individuals from 180 families. RESULTS: These data show that several single nucleotide polymorphisms in all three genes were associated with phonological memory, vocabulary, and reading decoding, with P less than 0.05. Notably, associations in AVPR1A (rs11832266) were significant after multiple testing correction. Gene-level tests showed that DRD2 was associated with vocabulary, ASPM with vocabulary and reading decoding, and AVPR1A with all three endophenotypes. CONCLUSION: Endophenotypes common to SSD, language impairment, and reading disability are all associated with these neuronal pathway genes.
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Authors | Catherine M Stein, Barbara Truitt, Fenghua Deng, Allison Avrich Ciesla, Feiyou Qiu, Peronne Joseph, Rekha Raghavendra, Jeremy Fondran, Robert P Igo Jr, Jessica Tag, Lisa Freebairn, H Gerry Taylor, Barbara A Lewis, Sudha K Iyengar |
Journal | Psychiatric genetics
(Psychiatr Genet)
Vol. 24
Issue 5
Pg. 191-200
(Oct 2014)
ISSN: 1473-5873 [Electronic] England |
PMID | 24849541
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- ASPM protein, human
- DRD2 protein, human
- Nerve Tissue Proteins
- Receptors, Dopamine D2
- Receptors, Vasopressin
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Topics |
- Child
- Child, Preschool
- Communication Disorders
(genetics)
- Endophenotypes
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Language Disorders
(genetics)
- Linkage Disequilibrium
(genetics)
- Male
- Nerve Tissue Proteins
(genetics)
- Quantitative Trait, Heritable
- Receptors, Dopamine D2
(genetics)
- Receptors, Vasopressin
(genetics)
- Speech Sound Disorder
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