Preparation, characterization, and pharmacodynamics of thermosensitive liposomes containing docetaxel.
|
| Abstract |
A novel thermosensitive liposome (TL) containing docetaxel (DTX) was designed to enhance DTX-targeted delivery and antitumor effect. TL loading DTX (DTX-TL) were prepared by thin film hydration. The mean particle size of the liposomes was about 100 nm, and the drug entrapment efficiency was more than 95%. The phase transition temperature of liposomes was about 42 °C. In vitro drug release showed that drug released at 37 °C was obviously less than that at 42 °C. For in vivo experiments, the human breast tumor model was established by subcutaneous xenotransplantation on nude mice; liposomes and injection containing DTX were injected i.v. in nude mice, followed by exposure of the tumors to hyperthermia (HT) for 30 min after administration. The tumor inhibition ratio of DTX-TL group was significantly higher than the normal injection group. Combining TL with HT enhanced the delivery of DTX and thereby its antitumor effects. The liposomes reported in this paper could potentially produce viable clinical strategies for improved targeting and delivery of DTX for the treatment of breast cancer.
|
|---|---|
| Authors | Hui Zhang, Wei Gong, Zhi-Yuan Wang, Shou-Jun Yuan, Xiang-Yang Xie, Yan-Fang Yang, Yang Yang, Shan-Shan Wang, De-Xuan Yang, Zi-Xue Xuan, Xing-Guo Mei |
| Journal | Journal of pharmaceutical sciences (J Pharm Sci) Vol. 103 Issue 7 Pg. 2177-2183 (Jul 2014) ISSN: 1520-6017 [Electronic] United States |
| PMID | 24846075 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association. |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!