Idebenone loaded solid lipid nanoparticles: calorimetric studies on surfactant and drug loading effects.

Abstract

In this study we prepared solid lipid nanoparticles (SLN), by the phase inversion temperature (PIT) method, using cetyl palmitate as solid lipid and three different non-ionic emulsifiers of the polyoxyethylene ethers family (ceteth-20, isoceteth-20, oleth-20). These SLN were loaded with different amount of idebenone (IDE), an antioxidant drug useful in the treatment of neurodegenerative diseases and skin oxidative damages. The differential scanning calorimetry (DSC) was employed to evaluate the effects of the different emulsifiers and the different amounts of drug loaded on the thermotropic behavior of SLN and to investigate how the drug was arranged into these nanoparticles. The IDE seemed to be located into different regions of the SLN depending on its concentration and on the surfactant used. The results of this study suggest that the calorimetric studies performed on SLN could provide valuable information to optimize SLN design and drug release from these carriers.

• Authors: Maria Grazia Sarpietro, Maria Lorena Accolla, Giovanni Puglisi, Francesco Castelli, Lucia Montenegro
• Journal: International journal of pharmaceutics (Int J Pharm) Vol. 471 Issue 1-2 Pg. 69-74 (Aug 25 2014) ISSN: 1873-3476 [Electronic] Netherlands
• PMID: 24845103 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Antioxidants
• Drug Carriers
• Ethers
• Palmitates
• Surface-Active Agents
• Ubiquinone
• Polyethylene Glycols
• cetyl palmitate
• idebenone

Topics

• Antioxidants (administration & dosage, chemistry)
• Calorimetry, Differential Scanning
• Drug Carriers (chemistry)
• Drug Compounding
• Drug Liberation
• Drug Stability
• Ethers
• Microscopy, Electron, Transmission
• Molecular Structure
• Nanoparticles (chemistry)
• Palmitates (chemistry)
• Particle Size
• Polyethylene Glycols (chemistry)
• Surface Properties
• Surface-Active Agents (chemistry)
• Transition Temperature
• Ubiquinone (administration & dosage, analogs & derivatives, chemistry)