Abstract | UNLABELLED: Aims/Introduction: Although the improvement of postprandial hyperglycemia by an alpha-glucosidase inhibitor (α-GI) has been associated with a risk reduction of cardiovascular events, the relationship between postprandial hyperglycemia and arterial stiffness has not been well understood. We therefore examined whether ameliorating the postprandial state by α-GI leads to an improvement in arterial stiffness. MATERIALS AND METHODS: A total of 22 patients with type 2 diabetes mellitus were treated with acarbose. Cardio-ankle vascular index (CAVI) as the arterial stiffness was measured by using a VaSera CAVI instrument before and 12 months after acarbose treatment. Serum high-sensitivity C-reactive protein ( hs-CRP), pentraxin-3 (PTX3) and matrix metalloproteinase ( MMP) -2, -9 were measured at the same time points. Furthermore, circulating peripheral blood mononuclear cells were examined for the frequencies of CD14 positive cells expressing membrane type-1 MMP (MT1-MMP) at the single cell level using flow cytometry. RESULTS: After acarbose treatment, postprandial glucose and glycosylated hemoglobin (HbA1c) were significantly decreased. Serum levels of hs-CRP, PTX3, MMP-2 and MMP-9 were significantly decreased. CAVI showed a significant reduction, although the changes were not significant in blood pressure and heart rate. MT1-MMP expression was significantly decreased by acarbose treatment. In multivariate analysis, improvement of blood glucose, decrease of PTX3 levels and MT1-MMP expression were independent predictors of beneficial change in CAVI. CONCLUSIONS:
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Authors | Hiroyasu Uzui, Akira Nakano, Yasuhiko Mitsuke, Toru Geshi, Junji Sakata, Katsuhiko Sarazawa, Tetsuji Morishita, Takehiko Satou, Kentarou Ishida, Jong-Dae Lee |
Journal | Journal of diabetes investigation
(J Diabetes Investig)
Vol. 2
Issue 2
Pg. 148-53
(Apr 07 2011)
ISSN: 2040-1116 [Print] Japan |
PMID | 24843474
(Publication Type: Journal Article)
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