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Effects of perioperatively administered dexamethasone on surgical wound healing in patients undergoing surgery for zygomatic fracture: a prospective study.

AbstractOBJECTIVE:
The aims of the study were to clarify the occurrence of disturbance in surgical wound healing (DSWH) after surgery of zygomatic complex (ZC) fractures and to determine whether perioperatively applied dexamethasone increases the risk for DSWH.
STUDY DESIGN:
Of 64 patients who were included in a single-blind prospective trial, 33 perioperatively received a total dose of 10 mg or 30 mg of dexamethasone. The remaining 31 patients served as controls.
RESULTS:
DSWH occurred in 9 patients (14.1%). Occurrence of DSWH was 24.4% in patients who received dexamethasone and 3.2% in controls. The association between DSWH and dexamethasone was significant (P = .016). Intraoral approach also was associated with DSWH significantly (P = .042). No association emerged between DSWH and age, gender, time span from accident to surgery, or duration of surgery.
CONCLUSIONS:
DSWH occurred significantly more frequently in patients who received perioperative dexamethasone. Because of increased risk of DSWH, perioperative dexamethasone cannot be recommended in open reduction and fixation of ZC fractures.
AuthorsJohanna Snäll, Eeva Kormi, Anna-Maria Koivusalo, Christian Lindqvist, Anna Liisa Suominen, Jyrki Törnwall, Hanna Thorén
JournalOral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 117 Issue 6 Pg. 685-9 (Jun 2014) ISSN: 2212-4411 [Electronic] United States
PMID24842445 (Publication Type: Journal Article, Randomized Controlled Trial)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Glucocorticoids
  • Dexamethasone
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Dexamethasone (therapeutic use)
  • Female
  • Fracture Fixation, Internal (methods)
  • Glucocorticoids (therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Single-Blind Method
  • Treatment Outcome
  • Wound Healing (drug effects)
  • Zygomatic Fractures (surgery)

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