Anxiety disorders and anxiety-related traits and serotonin transporter gene-linked polymorphic region (5-HTTLPR) in adolescents: case-control and trio studies.

Abstract	The role of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) in anxiety disorder and anxiety-related traits is controversial. Besides this study, few studies have evaluated the triallelic genotype in adolescents. The aim of this study was to investigate whether anxiety disorders and anxiety-related traits are associated with 5-HTTLPR (biallelic and triallelic) in adolescents, integrating both case-control-based and family-based designs in a community sample. This is a cross-sectional community study of 504 individuals and their families: 225 adolescents (129 adolescents with anxiety disorder and 96 controls) and their biological families. We assessed psychiatric diagnosis using the Kiddie Schedule for Affective Disorders and Schizophrenia. The Temperament and Character Inventory and the Resnick Behavioral Inhibition Scale were used to evaluate harm avoidance and behavioral inhibition. DNA was extracted from saliva and genotyped, including biallelic and triallelic 5-HTTLPR classification, by PCR-RFLP followed by agarose gel electrophoresis. We were not able to find any associations between 5-HTTLPR and anxiety-related phenotypes in both case-control and trio analyses. Further investigation and meta-analytic studies are needed to better clarify the inconsistent results with regard to the association between 5-HTTLPR and anxiety-related phenotypes in adolescents.
Authors	Andressa Bortoluzzi, Carolina Blaya, Giovanni A Salum, Carolina Cappi, Sandra Leistner-Segal, Gisele G Manfro
Journal	Psychiatric genetics (Psychiatr Genet) Vol. 24 Issue 4 Pg. 176-80 (Aug 2014) ISSN: 1473-5873 [Electronic] England
PMID	24842237 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	SLC6A4 protein, human Serotonin Plasma Membrane Transport Proteins
Topics	Adolescent Alleles Anxiety (genetics) Anxiety Disorders (genetics) Case-Control Studies Child Family Female Genetic Predisposition to Disease Humans Male Quantitative Trait, Heritable Serotonin Plasma Membrane Transport Proteins (genetics)

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