Abstract | PURPOSE: METHODS: RESULTS: A total of 4,144 lines of therapy were received by 3,191 patients from 46 practices across three states. Overall, there were 472 ED visits/hospitalizations for neutropenia, 34 visits for anemia, and 799 visits for CINV. G-CSF pathway-compliant treatment was associated with a significant reduction in neutropenia ED visits/hospitalizations compared with noncompliant treatment (odds ratio [OR] = 0.34; 95% CI, 0.25 to 0.45; P < .001). Adjusting for cancer type and G-CSF drug expenditures, a similar reduction in neutropenia ED visits/hospitalizations was observed (OR = 0.42; 95% CI 0.30 to 0.58; P < .001). Analogous analyses did not demonstrate a significant association between ESA and antiemetic pathway compliance and ED visits/hospitalizations for anemia (P = .069) and CINV (P = .106), respectively. G-CSF therapy pathway compliance was also associated with an average decrease of $1,085 in ED visit/hospitalization costs per line of therapy (P < .001). CONCLUSION:
G-CSF pathway compliance was associated with a significant decrease in the rate of neutropenia ED visits/hospitalizations and resulting costs.
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Authors | Eugene D Kreys, Ted Y Kim, Andrew Delgado, Jim M Koeller |
Journal | Journal of oncology practice
(J Oncol Pract)
Vol. 10
Issue 3
Pg. 168-73
(May 2014)
ISSN: 1935-469X [Electronic] United States |
PMID | 24839275
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 by American Society of Clinical Oncology. |
Chemical References |
- Antineoplastic Agents
- Hematinics
- Granulocyte Colony-Stimulating Factor
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Topics |
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Breast Neoplasms
(drug therapy)
- Colorectal Neoplasms
(drug therapy)
- Emergency Service, Hospital
- Granulocyte Colony-Stimulating Factor
(economics, therapeutic use)
- Hematinics
(economics, therapeutic use)
- Hospitalization
(economics, statistics & numerical data)
- Humans
- Lung Neoplasms
(drug therapy)
- Medication Adherence
- Neutropenia
(chemically induced, economics, prevention & control)
- Palliative Care
- Retrospective Studies
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