Evaluation of the benefit of addition of clidinium C to a Helicobacter pylori eradication regimen.

Abstract

AIM:

This study aimed to evaluate the success of H.pylori eradication therapy in patients with dyspepsia by therapeutics regimes with and without clidinium C.

BACKGROUND:

Helicobacter pylori infections are reported in all parts of the world. Appropriate antibiotic therapy can treat infection. The ideal treatment regimen has not been specified.

PATIENTS AND METHODS:

In a randomized, double blind clinical trials study, 250 patients with dyspepsia were enrolled. All patients were treated by Omeprazole, Metronidazole, Amoxicillin and Bismuth (OMAB) for two weeks. One tablet clidinium C before each meal was added to this regimen in the intervention group (A). Urea Breath Test (UBT) was carried out after 8-12 weeks after treatment for evaluation of H.pylori eradication.

RESULTS:

132 patients in the intervention group (A) and 118 patients in the control group (B) were enrolled to the study. The rate of eradication in group A was significantly higher than group B (62.1% vs. 50%, p=0.04).

CONCLUSION:

The results supported the effect of clidinium C for increasing of helicobacter pylori eradication, but further studies need to be performed.

• Authors: Maryam Chorami, Homayoun Zojaji, Nosratollah Naderi, Bijan Moghimi-Dehkordi, Dariush Mirsattari, Hamid Mohaghegh Shalmani
• Journal: Gastroenterology and hepatology from bed to bench (Gastroenterol Hepatol Bed Bench) Vol. 6 Issue 3 Pg. 141-5 ( 2013) ISSN: 2008-2258 [Print] Iran
• PMID: 24834261 (Publication Type: Journal Article)