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Radiation pneumonitis in patients with non--small-cell lung cancer treated with erlotinib concurrent with thoracic radiotherapy.

AbstractINTRODUCTION:
The aim of this study was to investigate the incidence of radiation pneumonitis in patients with non-small-cell lung cancer treated with concurrent thoracic radiotherapy and erlotinib.
METHODS:
Patients with inoperable stages IIIA to IV non-small-cell lung cancer who were treated with concurrent thoracic radiotherapy and erlotinib were analyzed. The incidence of radiation pneumonitis was evaluated using the Common Toxicity Criteria (CTC) 3.0 Grading System. The development of grade 2 or higher radiation pneumonitis was the study end point.
RESULTS:
Among the 24 patients analyzed, there were nine developed radiation pneumonitis of grade 2 or higher (37.5%), including four cases of grade 2 radiation pneumonitis (16.7%), two of grade 3 radiation pneumonitis (8.3%), and three of grade 5 radiation pneumonitis (12.5%). Three patients developed fatal pneumonia and died of bilateral lung radiation pneumonitis.
CONCLUSIONS:
Radiation pneumonitis should be considered in patients treated with concurrent thoracic radiotherapy and erlotinib.
AuthorsHongqing Zhuang, Zhiyong Yuan, Joe Y Chang, Jun Wang, Qingsong Pang, Lujun Zhao, Ping Wang
JournalJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (J Thorac Oncol) Vol. 9 Issue 6 Pg. 882-5 (Jun 2014) ISSN: 1556-1380 [Electronic] United States
PMID24828665 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Quinazolines
  • Erlotinib Hydrochloride
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents (therapeutic use)
  • Carcinoma, Non-Small-Cell Lung (therapy)
  • Chemoradiotherapy (adverse effects)
  • Erlotinib Hydrochloride
  • Female
  • Humans
  • Lung Neoplasms (therapy)
  • Male
  • Middle Aged
  • Quinazolines (therapeutic use)
  • Radiation Pneumonitis (diagnostic imaging, etiology)
  • Radiography
  • Severity of Illness Index

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