Abstract | PURPOSE: METHODS:
Oral mucositis was induced in the cheek pouch by X-irradiation using single doses in the range 20-50 Gy. To evaluate the protective effect of palifermin, administration was carried out (5 mg/kg) on days 1, 2 and 3 or on days 9, 10 and 11 after single irradiation at a dose of 40 Gy. RESULTS: The oral mucositis score, MPO activity and histopathological findings of inflammation increased in a dose dependent manner. Palifermin treatment stimulated the proliferation of mucosal epithelial cells. Additionally, palifermin when administered on days 1, 2 and 3 after irradiation (40 Gy) reduced the severity of oral mucositis. CONCLUSIONS: The hamster was found to be a suitable model for radiation-induced oral mucositis, with excellent results regarding the evaluation of radiation dose response and drug reactivity.
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Authors | Shinichi Watanabe, Katsuya Suemaru, Miki Nakanishi, Noriko Nakajima, Mamoru Tanaka, Akihiro Tanaka, Hiroaki Araki |
Journal | International journal of radiation biology
(Int J Radiat Biol)
Vol. 90
Issue 10
Pg. 884-91
(Oct 2014)
ISSN: 1362-3095 [Electronic] England |
PMID | 24827853
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Radiation-Protective Agents
- Fibroblast Growth Factor 7
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Topics |
- Animals
- Cheek
(pathology, radiation effects)
- Cricetinae
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- Fibroblast Growth Factor 7
(administration & dosage)
- Humans
- Mesocricetus
- Radiation Dosage
- Radiation Injuries
(pathology, prevention & control)
- Radiation Tolerance
(drug effects)
- Radiation-Protective Agents
(administration & dosage)
- Stomatitis
(pathology, prevention & control)
- Treatment Outcome
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