Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro.

Abstract

Furanodiene is a bioactive compound isolated from Curcuma wenyujin Y. H. Chen et C. Ling (C. wenyujin). It is one of the major components of volatile oil extracted from C. wenyujin. Furanodiene has anti-tumor activities in various cancer cell lines, as well as anti-metastatic activities. However, the underlying mechanisms of anti-metastatic activities of furanodiene have not been well investigated. In this study, we demonstrated that at low concentrations (5-25μM), furanodiene inhibited adhesion, migration and invasion of breast cancer cells, but it did not induce cytotoxicity, apoptosis and cell cycle arrest. Furthermore, the underlying mechanisms for the anti-metastatic activity of furanodinene were also investigated. Furanodiene down-regulated the integrin αV expression, β-catenin expression, focal adhesion kinase (FAK) phosphorylation, Akt phosphorylation, and PI3 kinase p85 phosphorylation, and all of these were involved in modulation of the tumor metastasis process. In addition, an interference of metastasis was also observed in MDA-MB-231 cells through the regulation of the matrix metalloproteinase 9 (MMP-9) releases. Our results suggested that furanodiene might be the primary contributor to the anti-cancer effects of volatile oil extracts, and it might be a good therapeutic target for highly metastatic breast cancer.

• Authors: Zhangfeng Zhong, Wen Tan, Xiuping Chen, Yitao Wang
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 737 Pg. 1-10 (Aug 15 2014) ISSN: 1879-0712 [Electronic] Netherlands
• PMID: 24824922 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents
• Biological Products
• Furans
• Heterocyclic Compounds, 2-Ring
• furanodiene
• Matrix Metalloproteinase 9
• Tetradecanoylphorbol Acetate

Topics

• Antineoplastic Agents (chemistry, pharmacology)
• Biological Products (chemistry, pharmacology)
• Breast Neoplasms (pathology)
• Cell Adhesion (drug effects)
• Cell Line, Tumor
• Cell Movement (drug effects)
• Furans (chemistry, pharmacology)
• Gene Expression Regulation, Neoplastic (drug effects)
• Heterocyclic Compounds, 2-Ring (chemistry, pharmacology)
• Humans
• Matrix Metalloproteinase 9 (metabolism)
• Neoplasm Invasiveness
• Neoplasm Metastasis
• Tetradecanoylphorbol Acetate (pharmacology)