Abstract | OBJECTIVE: METHODS: One Echinococcus multilocularis-infected rat served as control. Another 19 infected rats were infused with 0.2ml liposome entrapped albendazole and iodized oil suspension through portal vein. At 4, 7 and 10 d after treatment, the rats were sacrificed for further observation. The E. multilocularis metacestodes were collected, and the pathological change of alveolar hydatid was observed with hematoxylin- eosin staining and toluidine blue staining. RESULTS: In four days post treatment, E. multilocularis metacestodes were normal On the 7th day and 10th day post treatment, the major pathological change was degeneration and necrosis, respectively. A great quantity of liposomes and iodized oil deposited in the metacestodes, and caused breakdown of E. multilocularis tissue, collapse of cysts, cataplasia of germinal layer and laminated layer. CONCLUSION:
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Authors | Di-Wen Zhu, Hai-Xiao Zhang, Wei-Xin Ren, Jin Xiong, Xiao-Hui Xu, Hao Wen |
Journal | Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
(Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi)
Vol. 32
Issue 1
Pg. 58-61
(Feb 2014)
ISSN: 1000-7423 [Print] China |
PMID | 24822368
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Albendazole
- Animals
- Echinococcosis, Hepatic
(pathology, therapy)
- Echinococcus multilocularis
- Embolization, Therapeutic
- Necrosis
- Portal Vein
(pathology)
- Rats
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