Intraperitoneal curcumin decreased lung, renal and heart injury in abdominal aorta ischemia/reperfusion model in rat.

Abstract

BACKGROUND:

Previous studies have demonstrated that curcumin (CUR) has protective effects against ischemia reperfusion injury to various organs. We aimed to determine whether CUR has favorable effects on tissues and oxidative stress in abdominal aorta ischemia-reperfusion injury.

MATERIALS AND METHODS:

Thirty rats were divided into three groups as sham, control and treatment (CUR) group. Control and CUR groups underwent abdominal aorta ischemia for 60 min followed by a 120 min period of reperfusion. In the CUR group, CUR was given 5 min before reperfusion at a dose of 200 mg/kg via an intraperitoneal route. Total antioxidant capacity (TAC), total oxidative status (TOS), and oxidative stress index (OSI) in blood serum were measured, and lung, renal and heart tissue histopathology were evaluated with light microscopy.

RESULTS:

TOS and OSI activity in blood samples were statistically decreased in sham and CUR groups compared to the control group (p < 0.001 for TOS and OSI). Renal, lung, heart injury scores of sham and CUR groups were statistically decreased compared to control group (p < 0.001 for all comparisons). Histopathological examination revealed less severe lesions in CUR group than in the control group.

CONCLUSION:

CUR administered intraperitoneally was effective in reducing oxidative stress and histopathologic injury in an acute abdominal aorta I/R rat model.

• Authors: Mehmet Salih Aydin, Ahmet Caliskan, Aydemir Kocarslan, Sezen Kocarslan, Ali Yildiz, Samil Günay, Emin Savik, Abdussemet Hazar, Funda Yalcin
• Journal: International journal of surgery (London, England) (Int J Surg) Vol. 12 Issue 6 Pg. 601-5 ( 2014) ISSN: 1743-9159 [Electronic] England
• PMID: 24815029 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Antioxidants
• Curcumin

Topics

• Animals
• Antioxidants (administration & dosage, pharmacology, therapeutic use)
• Aorta, Abdominal
• Coronary Vessels (pathology)
• Curcumin (administration & dosage, pharmacology, therapeutic use)
• Disease Models, Animal
• Drug Evaluation, Preclinical (methods)
• Injections, Intraperitoneal
• Kidney (blood supply, pathology)
• Lung (blood supply, pathology)
• Male
• Oxidative Stress (drug effects)
• Rats, Wistar
• Reperfusion Injury (pathology, prevention & control)