Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection.

Abstract

A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.

• Authors: Christopher R M Asquith, Marina L Meli, Lidia S Konstantinova, Tuomo Laitinen, Mikael Peräkylä, Antti Poso, Oleg A Rakitin, Karin Allenspach, Regina Hofmann-Lehmann, Stephen T Hilton
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 24 Issue 12 Pg. 2640-4 (Jun 15 2014) ISSN: 1464-3405 [Electronic] England
• PMID: 24813732 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Capsid Proteins
• Pyrroles
• Small Molecule Libraries
• Thiazines

Topics

• Animals
• Capsid Proteins (metabolism)
• Cats
• Cell Line
• Cell Survival (drug effects)
• Disease Models, Animal
• HIV Infections (drug therapy)
• Humans
• Immunodeficiency Virus, Feline (drug effects)
• Molecular Structure
• Pyrroles (chemical synthesis, chemistry, pharmacology)
• Small Molecule Libraries (chemical synthesis, chemistry, pharmacology)
• Thiazines (chemical synthesis, chemistry, pharmacology)