Currently, natural products have been used in treating
gouty arthritis and are recognized as
xanthine oxidase inhibitors. Current study was designed to evaluate in vitro
xanthine oxidase inhibitory potential of Gouticin and its ingredients extracts and in vivo hypouricemic activity of gouticin
tablet 500 mg twice daily.
Ethanol extracts of Gouticin and its ingredients were evaluated in vitro, at 200, 100, 50, 25 μ g/ml concentrations for
xanthine oxidase inhibitory activity. IC(50) values of Gouticin and its ingredients were estimated. Further, in vivo
therapeutic effect of Gouticin was investigated in comparison with allopathic medicine (
Allopurinol) to treat
gout. Total patients were 200 that were divided into test and control group. Herbal coded medicine (Gouticin) was given to test group and allopathic medicine
allopurinol was administered to control group. In vitro, Gouticin has the highest percent inhibition at 96% followed by
Allopurinol with 93% inhibition. In vivo study, mean serum
uric acid level of patients was 4.62 mg/dl and 5.21mg/dl by use of Gouticin and
Allopurinol at end of
therapy. The study showed that herbal coded formulation gouticin and its ingredients are potential sources of natural
xanthine oxidase inhibitors. Gouticin 500 mg twice daily is more effective than the
allopurinol 300mg once daily in the management of
gout.