Abstract | BACKGROUND: OBSERVATIONS: We report a series of two patients with stage IV metastatic melanoma who presented to our Dermatology clinic for evaluation of a florid eruption of hyperkeratotic neoplasms (verrucae, actinic keratoses, and SCCs) within one month of initiating vemurafenib. After one month of acitretin, substantially fewer new neoplasms were observed in both patients. CONCLUSIONS: Although not definitive, these cases suggest that acitretin may have a role in chemoprevention of a subset of patients with rapidly developing vemurafenib-associated neoplasms and slowing the progression of more aggressive SCCs and KAs. Future studies to evaluate acitretin may substantially improve the morbidity associated with vemurafenib.
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Authors | Susan Y Chon, Brittany L Sambrano, Elizabeth R Geddes |
Journal | Journal of drugs in dermatology : JDD
(J Drugs Dermatol)
Vol. 13
Issue 5
Pg. 586-8
(May 2014)
ISSN: 1545-9616 [Print] United States |
PMID | 24809883
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Indoles
- Keratolytic Agents
- Sulfonamides
- Vemurafenib
- Acitretin
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Topics |
- Acitretin
(therapeutic use)
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Carcinoma, Squamous Cell
(chemically induced, prevention & control)
- Chemoprevention
(methods)
- Disease Progression
- Female
- Follow-Up Studies
- Humans
- Indoles
(adverse effects, therapeutic use)
- Keratolytic Agents
(therapeutic use)
- Melanoma
(drug therapy, pathology)
- Middle Aged
- Neoplasm Staging
- Skin Neoplasms
(drug therapy, pathology, prevention & control)
- Sulfonamides
(adverse effects, therapeutic use)
- Vemurafenib
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