Association between inflammatory biomarkers in plasma, radiological severity, and duration of exposure in patients with silicosis.

Abstract

OBJECTIVE:

To evaluate the plasma levels of CCL2, CCL3, CCL11, CCL24, tumor necrosis factor alpha, sTNFR1, and sTNFR2 in subjects exposed to silica (SES) with and without silicosis compared with unexposed reference control group, and their associations with the radiological severity and duration of exposure to silica.

METHODS:

Fifty-seven SES; 36 with silicosis and 22 subjects in control group, were included in the study.

RESULTS:

CCL3, CCL24, sTNFR1, and sTNFR2 were increased in SES and in SES with silicosis than in controls. There were no differences in the levels of CCL2, CCL11, or tumor necrosis factor alpha. The sTNFR2 level was greater in SES with silicosis than in SES without silicosis. There was a positive correlation between sTNFR1 and sTNFR2 and the radiological severity and time of exposure to silica. sTNFR2 was associated with all categories of radiological severity.

CONCLUSION:

sTNFR2 is associated with silicosis severity and early exposure to silica.

• Authors: Nayara Felicidade Tomaz Braz, Ana Paula Scalia Carneiro, Mateus Ramos Amorim, Fernanda de Oliveira Ferreira, Ana Cristina Rodrigues Lacerda, Aline Silva de Miranda, Mauro Martins Teixeira, Antonio Lucio Teixeira, Vanessa Amaral Mendonça
• Journal: Journal of occupational and environmental medicine (J Occup Environ Med) Vol. 56 Issue 5 Pg. 493-7 (May 2014) ISSN: 1536-5948 [Electronic] United States
• PMID: 24806562 (Publication Type: Comparative Study, Journal Article, Observational Study, Research Support, Non-U.S. Gov't)

Chemical References

• Air Pollutants, Occupational
• Biomarkers
• Chemokines, CC
• Receptors, Tumor Necrosis Factor, Type I
• Receptors, Tumor Necrosis Factor, Type II
• Tumor Necrosis Factor-alpha
• Silicon Dioxide

Topics

• Adult
• Air Pollutants, Occupational
• Biomarkers (blood)
• Chemokines, CC (blood)
• Dose-Response Relationship, Radiation
• Humans
• Immune System (radiation effects)
• Male
• Middle Aged
• Occupational Exposure
• Radiography, Thoracic
• Receptors, Tumor Necrosis Factor, Type I (blood)
• Receptors, Tumor Necrosis Factor, Type II (blood)
• Silicon Dioxide (administration & dosage, metabolism)
• Silicosis (etiology)
• Tumor Necrosis Factor-alpha (blood)