Abstract | PURPOSE: METHODS:
Nocturia was assessed using Question 7 of the International Prostate Symptom Score questionnaire. Efficacy measures included as follows: mean change in nocturia at 3-month intervals up to 48 months; proportion of patients with improvement/worsening in nocturia; nocturnal voiding frequency at baseline and study end, overall and by baseline subgroups; and nocturnal voiding frequency <2 at study end in patients with a baseline score ≥ 2. RESULTS: In total, 4,722 patients with a mean age of 66 years were included. Mean nocturia improvements were significantly superior (p ≤ 0.01) with combination therapy than with either monotherapy (adjusted mean change from baseline in IPSS Question 7 score at month 48: combination therapy -0.5, dutasteride -0.4, tamsulosin -0.3). Reduction in nocturia score with combination therapy was significantly (p ≤ 0.01) better than tamsulosin monotherapy across all baseline subgroups tested, except for men with previous 5ARI use. Among those with a baseline IPSS Q7 score ≥ 2, more patients with combination therapy had a score <2 at month 48 (34 %) compared with dutasteride (30 %, p = 0.018) or tamsulosin (26 %, p < 0.0001). CONCLUSIONS: Combination therapy provided greater improvements and less worsening of nocturia compared with both dutasteride and tamsulosin monotherapies. These analyses are the first to show greater improvement with a 5ARI/α-blocker combination versus either agent alone for the management of nocturia in patients with LUTS/BPH.
|
Authors | Matthias Oelke, Claus G Roehrborn, Carlos D'Ancona, Timothy H Wilson, Ramiro Castro, Michael Manyak |
Journal | World journal of urology
(World J Urol)
Vol. 32
Issue 5
Pg. 1133-40
(Oct 2014)
ISSN: 1433-8726 [Electronic] Germany |
PMID | 24804842
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
|
Chemical References |
- 5-alpha Reductase Inhibitors
- Adrenergic alpha-1 Receptor Antagonists
- Azasteroids
- Drug Combinations
- Sulfonamides
- Tamsulosin
- Dutasteride
|
Topics |
- 5-alpha Reductase Inhibitors
(administration & dosage)
- Adrenergic alpha-1 Receptor Antagonists
(administration & dosage)
- Aged
- Azasteroids
(administration & dosage)
- Double-Blind Method
- Drug Combinations
- Dutasteride
- Humans
- Lower Urinary Tract Symptoms
(complications)
- Male
- Middle Aged
- Nocturia
(drug therapy, etiology)
- Prostatic Hyperplasia
(complications)
- Sulfonamides
(administration & dosage)
- Tamsulosin
|