Long-term progression of retinal vasculitis in Behçet patients using a fluorescein angiography scoring system.

Abstract

BACKGROUND:

To evaluate the long-time progression of retinal vasculitis in Behçet patients using the fluorescein angiography (FA) scoring system.

METHODS:

Retrospective study was conducted for 71 eyes of 43 patients who met the study criteria. All patients completed at least 2 years of follow-up. FA was taken during the periods of active retinal vasculitis and the quiescent phase, and analyzed using a FA scoring system. Among nine categories, the four most prevalent FA signs were evaluated: optic disc hyperfluorescence (score 0-3), macular edema (score 0-4), retinal vascular staining and/or leakage (score 0-7), and capillary leakage (score 0-10).

RESULTS:

Mean number of total active inflammations was 2.6 ± 1.5 times during mean 55.0 ± 20.0 months. Mean scores at the first active inflammation were 1.8 ± 1.0 for optic disc hyperfluorescence, 2.4 ± 1.0 for macular edema, 5.3 ± 2.1 for retinal vascular staining and/or leakage, and 5.8 ± 3.2 for capillary leakage. Mean total FA score was 17.4 ± 6.8. Mean scores at the first quiescent phase were 0.6 ± 0.4 for optic disc hyperfluorescence, 1.1 ± 1.2 for macular edema, 3.8 ± 1.9 for retinal vascular staining and/or leakage, and 3.5 ± 3.5 for capillary leakage. Mean total FA score was 9.1 ± 5.0. Mean scores for each active inflammation and quiescent phase were not significantly changed, and mean FA scores were significantly reduced in quiescent phase (P = 0.003 for optic disc hyperfluorescence, P = 0.005 for macular leakage, P = 0.010 for retinal vascular staining and/or leakage, P = 0.008 for capillary leakage, and P = 0.018 for total FA score; paired t-test).

CONCLUSIONS:

Retinal vasculitis of Behçet patients did not significantly progress during long-term follow-up.

• Authors: Hae Min Kang, Sung Chul Lee
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 252 Issue 6 Pg. 1001-8 (Jun 2014) ISSN: 1435-702X [Electronic] Germany
• PMID: 24796770 (Publication Type: Journal Article)

Chemical References

• Glucocorticoids
• Immunosuppressive Agents

Topics

• Adult
• Behcet Syndrome (diagnosis, drug therapy, physiopathology)
• Blood-Retinal Barrier
• Capillary Permeability
• Combined Modality Therapy
• Disease Progression
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Glucocorticoids (therapeutic use)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Male
• Middle Aged
• Retinal Vasculitis (diagnosis, drug therapy, physiopathology)
• Retrospective Studies
• Tomography, Optical Coherence
• Visual Acuity (physiology)
• Young Adult