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Camel's milk ameliorates TNBS-induced colitis in rats via downregulation of inflammatory cytokines and oxidative stress.

Abstract
Current treatment strategies for inflammatory bowel diseases (IBD) are associated with several adverse effects, and thus, the search for effective agents with minimal side effects merits attention. Camel's milk (CM) is endowed with antioxidant/anti-inflammatory features and has been reported to protect against diabetes and hepatic injury, however, its effects on IBD have not been previously explored. In the current study, we aimed to investigate the potential alleviating effects of CM against TNBS-induced colitis in rats. CM (10 ml/kg b.i.d. by oral gavage) effectively suppressed the severity of colon injury as evidenced by amelioration of macroscopic damage, colon weight/length ratio, histopathological alterations, leukocyte influx and myeloperoxidase activity. Administration of CM mitigated the colonic levels of TNF-α and IL-10 cytokines. The attenuation of CM to colon injury was also associated with suppression of oxidative stress via reduction of lipid peroxides and nitric oxide along with boosting the antioxidant defenses through restoration of colon glutathione and total anti-oxidant capacity. In addition, caspases-3 activity, an apoptotic marker, was inhibited. Together, our study highlights evidences for the promising alleviating effects of CM in colitis. Thus, CM may be an interesting complementary approach for the management of IBD.
AuthorsHany H Arab, Samir A Salama, Ahmed H Eid, Hany A Omar, El-Shaimaa A Arafa, Ibrahim A Maghrabi
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 69 Pg. 294-302 (Jul 2014) ISSN: 1873-6351 [Electronic] England
PMID24788059 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Caspase Inhibitors
  • Cytokines
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • Trinitrobenzenesulfonic Acid
  • Peroxidase
  • Caspase 3
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Antioxidants (metabolism)
  • Camelus
  • Caspase 3 (metabolism)
  • Caspase Inhibitors (pharmacology)
  • Colitis (chemically induced, drug therapy, pathology)
  • Cytokines (metabolism)
  • Down-Regulation (drug effects)
  • Interleukin-10 (metabolism)
  • Leukocytes (drug effects, pathology)
  • Milk
  • Oxidative Stress (drug effects)
  • Peroxidase (metabolism)
  • Rats, Wistar
  • Trinitrobenzenesulfonic Acid (toxicity)
  • Tumor Necrosis Factor-alpha (metabolism)

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