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Neutrophil energetics and oxygen sensing.

Abstract
In this issue of Blood, Jun et al, through the study of neutrophils deficient in the glucose-6-phosphate transporter, describe a novel role for the peroxisome proliferator-activated receptor-γ (PPARG) pathway in the regulation of key neutrophil functions and link this to concomitant hypoxia-inducible factor (HIF) 1α stabilization.
AuthorsSarah R Walmsley, Moira K B Whyte
JournalBlood (Blood) Vol. 123 Issue 18 Pg. 2753-4 (May 01 2014) ISSN: 1528-0020 [Electronic] United States
PMID24786455 (Publication Type: Journal Article, Comment)
Topics
  • Glycogen Storage Disease Type I (genetics, metabolism)
  • Humans
  • Neutrophils (metabolism)

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