Abstract | RATIONALE: OBJECTIVES: The aim of this study was to characterize prefrontal D1 receptor availability and its relation to WM performance in SPD. METHODS: We used positron emission tomography (PET) and the radiotracer [(11)C]NNC112 with 18 unmedicated SPD and 21 healthy control participants; as an index of D1 receptor availability, binding potential (BP) measures (BPF, BPND, and BPP) were calculated for prefrontal and striatal subregions. To assess WM, SPD participants completed the 2-back and Paced Auditory Serial Addition Test (PASAT). RESULTS: There were no significant group differences in PFC BP. BPF and BPP in the medial PFC were significantly negatively related to PASAT performance (r s = -0.551, p = .022 and r s = -0.488, p = .047, respectively), but BP was not related to 2-back performance. CONCLUSIONS: In contrast to what has been found in schizophrenia, SPD was not associated with significant alterations in prefrontal D1 receptor availability. Similar to previous schizophrenia findings, however, higher prefrontal D1 receptor availability was associated with poorer WM performance (as measured by the PASAT) in SPD. These findings suggest that schizophrenia and SPD may share a common pathophysiological feature related to prefrontal dopamine functioning that contributes to WM dysfunction, but that in SPD, alterations in D1 may occur only in a subset of individuals and/or to an extent that is minor relative to what occurs in schizophrenia.
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Authors | Judy L Thompson, Daniel R Rosell, Mark Slifstein, Ragy R Girgis, Xiaoyan Xu, Yosefa Ehrlich, Lawrence S Kegeles, Erin A Hazlett, Anissa Abi-Dargham, Larry J Siever |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 231
Issue 21
Pg. 4231-40
(Oct 2014)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 24781514
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Receptors, Dopamine D1
- Dopamine
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Topics |
- Adult
- Corpus Striatum
(diagnostic imaging, metabolism)
- Dopamine
(metabolism)
- Female
- Humans
- Male
- Memory, Short-Term
(physiology)
- Middle Aged
- Neuropsychological Tests
- Prefrontal Cortex
(diagnostic imaging, metabolism)
- Radionuclide Imaging
- Receptors, Dopamine D1
(metabolism)
- Schizotypal Personality Disorder
(diagnostic imaging, metabolism, psychology)
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