Abstract | BACKGROUND:
Xanthomas are well circumscribed lesions in the connective tissue of the skin, tendons or fasciae that predominantly consist of foam cells; these specific cells are formed from macrophages as a result of an excessive uptake of low density lipoprotein ( LDL) particles and their oxidative modification. RESULTS: CONCLUSION: Thorough familiarity with the clinical presentation of xanthomas helps in the diagnosis and follow-up of different forms of dyslipidemia. Moreover, xanthelasma palpebrarum, the most prevalent form of xanthomas, is connected with increased risk of atherothrombotic disease independently of conventional cardiovascular risk factors. To fully understand the pathogenesis, further experimental and clinical research is required.
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Authors | Ales Zak, Miroslav Zeman, Adolf Slaby, Marek Vecka |
Journal | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
(Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub)
Vol. 158
Issue 2
Pg. 181-8
(Jun 2014)
ISSN: 1804-7521 [Electronic] Czech Republic |
PMID | 24781043
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Topics |
- Humans
- Hyperlipidemias
(complications, drug therapy, metabolism)
- Skin Diseases
(classification, diagnosis, epidemiology, metabolism, therapy)
- Xanthomatosis
(classification, diagnosis, epidemiology, metabolism, therapy)
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