Alterations of the biomarker S-100B and NSE in patients with acute vertebral spine fractures.

Abstract

BACKGROUND CONTEXT:

Although several publications concerning the use of the biomarkers S100B and neuron-specific enolase (NSE) in vertebral spine fractures in animal experimental studies have proven their usefulness as early indicators of injury severity, there are no clinical reports on their effectiveness as indicators in patients with spinal injuries. As these biomarkers have been examined, with promising results, in patients with traumatic brain injury, there is a potential for their implementation in patients with vertebral spine fractures.

PURPOSE:

To investigate the early serum measurement of S100B and NSE in patients with vertebral spine fractures compared with those in patients with acute fractures of the proximal femur.

STUDY DESIGN:

Prospective longitudinal cohort study.

PATIENT SAMPLE:

A cohort of 34 patients admitted over an 18-month period to a single medical center for suspected vertebral spine trauma. Twenty-nine patients were included in the control group.

OUTCOME MEASURES:

S100B and NSE serum levels were assessed in different types of vertebral spine fractures.

METHODS:

We included patients older than 16 years with vertebral spine fractures whose injuries were sustained within 24 hours before admission to the emergency room and who had undergone a brief neurologic examination. Spinal cord injuries (SCIs) were classified as being paresthesias, incomplete paraplegias, or complete paraplegias. Blood serum was obtained from all patients within 24 hours after the time of injury. Serum levels of S100B and NSE were statistically analyzed using Wilcoxon signed-rank test.

RESULTS:

S100B serum levels were significantly higher in patients with vertebral spine fractures (p=.01). In these patients, the mean S100B serum level was 0.75 μg/L (standard deviation [SD] 1.44, 95% confidence interval [CI] 0.24, 1.25). The mean S100B serum level in control group patients was 0.14 μg/L (SD 0.11, 95% CI 0.10, 0.19). The 10 patients with neurologic deficits had significantly higher S100B serum levels compared with the patients with vertebral fractures but without neurologic deficits (p=.02). The mean S100B serum level in these patients was 1.18 μg/L (SD 1.96). In the 26 patients with vertebral spine fractures but without neurologic injury, the mean S100B serum level was 0.42 μg/L (SD 0.91, 95% CI 0.08, 0.76). The analysis revealed no significant difference in NSE levels.

CONCLUSIONS:

We observed a significant correlation not only between S100B serum levels and vertebral spine fractures but also between S100B serum levels and SCIs with neurologic deficit. These results may be meaningful in clinical practice and to future studies.

• Authors: Harald Wolf, Christoph Krall, Gholam Pajenda, Johannes Leitgeb, Adam J Bukaty, Stefan Hajdu, Kambiz Sarahrudi
• Journal: The spine journal : official journal of the North American Spine Society (Spine J) Vol. 14 Issue 12 Pg. 2918-22 (Dec 01 2014) ISSN: 1878-1632 [Electronic] United States
• PMID: 24780247 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• S100 Proteins
• Phosphopyruvate Hydratase

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Case-Control Studies
• Female
• Femoral Fractures (blood)
• Humans
• Male
• Middle Aged
• Phosphopyruvate Hydratase (blood)
• S100 Proteins (blood)
• Spinal Fractures (blood)