Abstract | BACKGROUND: METHODS: Case information was obtained from clinicians (4 patients) or a US Food and Drug Administration database (1 patient). RESULTS: All 5 patients had lymphoid malignancies. Two patients with cutaneous T-cell lymphomas had not previously received chemotherapy. PML developed after a median of 3 BV doses (range, 2 doses-6 doses) and within a median of 7 weeks after BV initiation (range, 3 weeks-34 weeks). Presenting findings included aphasia, dysarthria, confusion, hemiparesis, and gait dysfunction; JC virus in the cerebrospinal fluid (2 patients) or central nervous system biopsy (3 patients); and brain magnetic resonance imaging scans with white matter abnormalities (5 patients). Four patients died at a median of 8 weeks (range, 6 weeks-16 weeks) after PML diagnosis. The sole survivor developed immune reconstitution inflammatory syndrome. CONCLUSIONS: PML can develop after a few BV doses and within weeks of BV initiation. Clinicians should be aware of this syndrome, particularly when neurologic changes develop after the initiation of BV treatment. The decision to administer BV to patients with indolent cutaneous lymphomas should be based on consideration of risk-benefit profiles and of alternative options.
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Authors | Kenneth R Carson, Scott D Newsome, Ellen J Kim, Nina D Wagner-Johnston, Gloria von Geldern, Craig H Moskowitz, Alison J Moskowitz, Alain H Rook, Pankaj Jalan, Alison W Loren, Daniel Landsburg, Thomas Coyne, Donald Tsai, Dennis W Raisch, LeAnn B Norris, P Brandon Bookstaver, Oliver Sartor, Charles L Bennett |
Journal | Cancer
(Cancer)
Vol. 120
Issue 16
Pg. 2464-71
(Aug 15 2014)
ISSN: 1097-0142 [Electronic] United States |
PMID | 24771533
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 American Cancer Society. |
Chemical References |
- Immunoconjugates
- Brentuximab Vedotin
|
Topics |
- Adult
- Aged
- Brentuximab Vedotin
- Hodgkin Disease
(drug therapy)
- Humans
- Immunoconjugates
(adverse effects)
- Leukoencephalopathy, Progressive Multifocal
(chemically induced)
- Lymphoma, Primary Cutaneous Anaplastic Large Cell
(drug therapy)
- Middle Aged
- Mycosis Fungoides
(drug therapy)
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