Specific features of analgesic effect of docosahexaenoic acid in rats with neuropathic pain syndrome.

Abstract

Experiments on white rats showed that sciatic nerve ligation induced the development of neuropathic pain syndrome: thermal pain threshold decreased, significant reduction in weight bearing of the injured limb, and degenerative changes in the foot tissues. Administration of docosahexaenoic acid reduces activity and duration neuropathic pain syndrome, promoted reversion of weight bearing asymmetry, and prevented the development of degenerative changes in the foot tissues.

• Authors: I V Dyuizen, I V Manzhulo, O S Ogurtsova, N E Lamash, N A Latyshev, S V Kas'yanov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 156 Issue 5 Pg. 699-701 (Mar 2014) ISSN: 1573-8221 [Electronic] United States
• PMID: 24770761 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics, Non-Narcotic
• Docosahexaenoic Acids

Topics

• Analgesics, Non-Narcotic (pharmacology, therapeutic use)
• Animals
• Docosahexaenoic Acids (pharmacology, therapeutic use)
• Drug Evaluation, Preclinical
• Extremities (physiopathology)
• Hyperalgesia (drug therapy)
• Male
• Neuralgia (drug therapy)
• Rats, Sprague-Dawley
• Weight-Bearing