Perinatal biomarkers in prematurity: early identification of neurologic injury.

Abstract

Over the past few decades, biomarkers have become increasingly utilized as non-invasive tools in the early diagnosis and management of various clinical conditions. In perinatal medicine, the improved survival of extremely premature infants who are at high risk for adverse neurologic outcomes has increased the demand for the discovery of biomarkers in detecting and predicting the prognosis of infants with neonatal brain injury. By enabling the clinician to recognize potential brain damage early, biomarkers could allow clinicians to intervene at the early stages of disease, and to monitor the efficacy of those interventions. This review will first examine the potential perinatal biomarkers for neurologic complications of prematurity, specifically, intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL) and posthemorrhagic hydrocephalus (PHH). It will also evaluate knowledge gained from animal models regarding the pathogenesis of perinatal brain injury in prematurity.

• Authors: Maria Andrikopoulou, Ahmad Almalki, Azadeh Farzin, Christina N Cordeiro, Michael V Johnston, Irina Burd
• Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (Int J Dev Neurosci) Vol. 36 Pg. 25-31 (Aug 2014) ISSN: 1873-474X [Electronic] United States
• PMID: 24768951 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2014 ISDN. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers

Topics

• Animals
• Biomarkers (metabolism)
• Early Diagnosis
• Female
• Humans
• Infant, Premature (metabolism)
• Male
• Nervous System Diseases (complications, diagnosis, metabolism)
• Pregnancy