Abstract | PURPOSE: The purpose of this study was to investigate whether the signal intensity of the substantia nigra pars compacta (SNc) and locus coeruleus (LC) on neuromelanin-sensitive magnetic resonance imaging (MRI) can discriminate early-stage parkinsonism disorders, for which differential diagnosis is generally difficult. METHODS: RESULTS: The CR of the lateral SNc was lower in the PD and MSA-P groups than in the PSPS and control groups (p = 0.0001-0.05). The CR of the LC was lower in the PD group than in the other groups (p = 0.0001-0.05). Sensitivity and specificity of the CRs for discriminating PD from MSA-P was 60% and 90%, respectively, those for PD/PSPS were 63-88% and 77-92%, respectively, and those for MSA-P/PSPS were 80% and 85%, respectively. These properties were comparable or better to MIBG scintigraphy. CONCLUSIONS:
Neuromelanin-sensitive MRI can depict differences in signal intensity of the lateral SNc and the LC among the parkinsonism disorders at their early stages.
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Authors | Chigumi Ohtsuka, Makoto Sasaki, Kanako Konno, Kanako Kato, Junko Takahashi, Fumio Yamashita, Yasuo Terayama |
Journal | Parkinsonism & related disorders
(Parkinsonism Relat Disord)
Vol. 20
Issue 7
Pg. 755-60
(Jul 2014)
ISSN: 1873-5126 [Electronic] England |
PMID | 24768616
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Diagnosis, Differential
- Early Diagnosis
- Female
- Humans
- Locus Coeruleus
(metabolism, pathology)
- Magnetic Resonance Imaging
(methods)
- Male
- Melanins
- Middle Aged
- Parkinsonian Disorders
(diagnosis, metabolism)
- Substantia Nigra
(metabolism, pathology)
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