PIP2: choreographer of actin-adaptor proteins in the HIV-1 dance.

Abstract

The actin cytoskeleton plays a key role during the replication cycle of human immunodeficiency virus-1 (HIV-1). HIV-1 infection is affected by cellular proteins that influence the clustering of viral receptors or the subcortical actin cytoskeleton. Several of these actin-adaptor proteins are controlled by the second messenger phosphatidylinositol 4,5-biphosphate (PIP2), an important regulator of actin organization. PIP2 production is induced by HIV-1 attachment and facilitates viral infection. However, the importance of PIP2 in regulating cytoskeletal proteins and thus HIV-1 infection has been overlooked. This review examines recent reports describing the roles played by actin-adaptor proteins during HIV-1 infection of CD4+ T cells, highlighting the influence of the signaling lipid PIP2 in this process.

• Authors: Vera Rocha-Perugini, Mónica Gordon-Alonso, Francisco Sánchez-Madrid
• Journal: Trends in microbiology (Trends Microbiol) Vol. 22 Issue 7 Pg. 379-88 (Jul 2014) ISSN: 1878-4380 [Electronic] England
• PMID: 24768560 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Actins
• Adaptor Proteins, Signal Transducing
• Phosphatidylinositol 4,5-Diphosphate

Topics

• Actins (metabolism)
• Adaptor Proteins, Signal Transducing (metabolism)
• CD4-Positive T-Lymphocytes (physiology, virology)
• HIV-1 (physiology)
• Humans
• Phosphatidylinositol 4,5-Diphosphate (metabolism)
• Protein Multimerization
• Virus Internalization