Abstract | BACKGROUND & AIMS: METHODS: We conducted a retrospective chart review of patients with a confirmed diagnosis of PSC and IBD who underwent colectomy with IPAA followed by pouch surveillance between 1995 and 2012. RESULTS: Sixty-five patients were included in the cohort and were followed up from the time of colectomy/IPAA for a median of 6years. The most common indications for surgery were low-grade dysplasia (LGD) and refractory colitis. Only 3 patients developed evidence of neoplasia (LGD n=1, high-grade dysplasia n=1, adenocarcinoma n=1). The cumulative 5-year incidence of pouch neoplasia was 5.6% (95% confidence intervals [CI], 1.8%-16.1%). CONCLUSION: Based on our short-term follow-up, surveying the pouch frequently appears to be an unnecessary practice in PSC-IBD patients. Longer follow-up will be needed to develop an optimal surveillance strategy for the development of dysplasia and cancer in such patients.
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Authors | Mohamad H Imam, John E Eaton, Jason S Puckett, Edward V Loftus Jr, Kellie L Mathis, Andrea A Gossard, Jayant A Talwalkar, Keith D Lindor |
Journal | Journal of Crohn's & colitis
(J Crohns Colitis)
Vol. 8
Issue 10
Pg. 1294-9
(Oct 2014)
ISSN: 1876-4479 [Electronic] England |
PMID | 24768559
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved. |
Topics |
- Adenocarcinoma
(epidemiology)
- Adolescent
- Adult
- Anus Neoplasms
(epidemiology)
- Child
- Cholangitis, Sclerosing
(surgery)
- Colitis, Ulcerative
(surgery)
- Colonic Pouches
(pathology)
- Female
- Humans
- Ileal Neoplasms
(epidemiology)
- Incidence
- Male
- Middle Aged
- Population Surveillance
- Proctocolectomy, Restorative
- Retrospective Studies
- Time Factors
- Young Adult
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