[Diagnostic value of hepatobiliary phase imaging with GD-EOB-DTPA for hepatocellular carcinomas in cirrhosis].

Abstract

OBJECTIVE:

To assess the diagnostic value of hepatobiliary phase imaging with GD-EOB-DTPA for hepatocellular carcinomas (HCC) in cirrhosis.

METHODS:

A total of 43 cirrhotic patients with 45 HCC lesions underwent the examinations of T2WI, DWI, T1WI in-phase and opposed-phase and dynamic contrast enhancement and hepatobiliary phase. Two separate analyses of imaging set with and without hepatobiliary phase images were performed. The confidence scores for HCC diagnosis, consistency, area under the receiver operating characteristic (ROC) curve and sensitivity and positive predictive values of two observers were compared.

RESULTS:

After adding hepatobiliary phase, there was a significant increase of confidence scores in diagnosing HCC by both observers (P < 0.05) and the consistency of two observers also increased. The area under the ROC curve improved by both observers, but no significant differences were detected (P > 0.05). The sensitivity increased significantly (P < 0.05) and no significant differences were observed for the positive predictive values by both observers (P > 0.05).

CONCLUSION:

Hepatobiliary phase imaging may improve the diagnostic confidence and sensitivity of GD-EOB-DTPA for HCC in cirrhosis.

• Authors: Tao Zhang, Jian Lu, Xueqin Zhang, Hongwei Liang, Xiaofen Miao, Jifeng Jiang, Ding Ding, Xuefei Yang
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 94 Issue 7 Pg. 517-20 (Feb 25 2014) ISSN: 0376-2491 [Print] China
• PMID: 24767294 (Publication Type: English Abstract, Journal Article)

Chemical References

• gadolinium ethoxybenzyl DTPA
• Gadolinium DTPA

Topics

• Adult
• Aged
• Carcinoma, Hepatocellular (diagnosis)
• Female
• Gadolinium DTPA
• Humans
• Liver Cirrhosis (diagnosis, pathology)
• Liver Neoplasms (diagnosis)
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Predictive Value of Tests
• Sensitivity and Specificity