Abstract | BACKGROUND: METHODS: Forty-nine NVG eyes from 43 patients (26 males and 17 females) underwent primary trabeculectomy with MMC. The mean follow-up period was 16.8 ± 8.1 months (range, 6 to 34 months). Twenty-one eyes of 21 patients received intravitreal bevacizumab (IVB) 3.6 ± 1.8 days before trabeculectomy with MMC. A Kaplan-Meier survival-curve analysis was used to summarize the cumulative probability of success. We examined the relationship between the surgical outcome and the following surgical factors: gender, age, history of panretinal photocoagulation, history of cataract surgery, history of vitrectomy, preoperative IVB, NVG in the fellow eye, and postoperative complications ( hyphema, choroidal detachment, and formation of fibrin) by multivariate analysis. RESULTS: The survival rate was 83.7% after 6 months, 70.9% after 12 months, and 60.8% after 24 months. The Kaplan-Meier survival curves showed no significant difference in the survival rate between the eyes with preoperative IVB (n = 21) and the eyes without preoperative IVB (n = 28) (p = 0.14). The multiple logistic regression analysis showed that postoperative hyphema (odds ratio, 6.54; 95% confidence interval, 1.41 to 35.97) was significantly associated with the surgical outcome (p = 0.02). CONCLUSIONS: Postoperative hyphema was significantly correlated with the outcome of trabeculectomy for NVG. There was no significant association between preoperative IVB and postoperative hyphema or the results of trabeculectomy.
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Authors | Shunji Nakatake, Shigeo Yoshida, Shintaro Nakao, Ryoichi Arita, Miho Yasuda, Takeshi Kita, Hiroshi Enaida, Yuji Ohshima, Tatsuro Ishibashi |
Journal | BMC ophthalmology
(BMC Ophthalmol)
Vol. 14
Pg. 55
(Apr 26 2014)
ISSN: 1471-2415 [Electronic] England |
PMID | 24766841
(Publication Type: Journal Article)
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Chemical References |
- Angiogenesis Inhibitors
- Antibodies, Monoclonal, Humanized
- Vascular Endothelial Growth Factor A
- Bevacizumab
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Topics |
- Adult
- Aged
- Angiogenesis Inhibitors
(administration & dosage)
- Antibodies, Monoclonal, Humanized
(administration & dosage)
- Bevacizumab
- Female
- Follow-Up Studies
- Glaucoma, Neovascular
(diagnosis, physiopathology, surgery)
- Humans
- Hyphema
(diagnosis, epidemiology, etiology)
- Incidence
- Intraocular Pressure
- Intravitreal Injections
- Japan
(epidemiology)
- Male
- Middle Aged
- Postoperative Hemorrhage
(epidemiology, etiology, prevention & control)
- Retrospective Studies
- Risk Factors
- Survival Rate
(trends)
- Time Factors
- Trabeculectomy
(adverse effects)
- Treatment Outcome
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
- Visual Acuity
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