Abstract |
Chondroitin sulfate proteoglycans (CSPGs) are a diverse family of extracellular matrix (ECM) molecules that make significant contributions to the patterning and routing of migrating neural cells and extending axons. Three distinct modes of migration mediation result from the relative abundance and positioning of expressed CSPGs, the profile of CSPG receptors expressed by the motile cell types, and the overall way in which the CSPGs integrate into and stabilize the neural ECM. Here we discuss recent findings that help to clarify the molecular mechanisms that underlie these distinct migration-regulating properties as they pertain to neural development, CNS injury, and gliomagenesis.
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Authors | Daniel J Silver, Jerry Silver |
Journal | Current opinion in neurobiology
(Curr Opin Neurobiol)
Vol. 27
Pg. 171-8
(Aug 2014)
ISSN: 1873-6882 [Electronic] England |
PMID | 24762654
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Chondroitin Sulfate Proteoglycans
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Topics |
- Animals
- Cell Movement
(physiology)
- Central Nervous System
(cytology, growth & development, metabolism)
- Central Nervous System Diseases
(metabolism)
- Chondroitin Sulfate Proteoglycans
(physiology)
- Humans
- Models, Biological
- Neoplasms
(metabolism)
- Neurons
(metabolism, physiology)
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