HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Contributions of chondroitin sulfate proteoglycans to neurodevelopment, injury, and cancer.

Abstract
Chondroitin sulfate proteoglycans (CSPGs) are a diverse family of extracellular matrix (ECM) molecules that make significant contributions to the patterning and routing of migrating neural cells and extending axons. Three distinct modes of migration mediation result from the relative abundance and positioning of expressed CSPGs, the profile of CSPG receptors expressed by the motile cell types, and the overall way in which the CSPGs integrate into and stabilize the neural ECM. Here we discuss recent findings that help to clarify the molecular mechanisms that underlie these distinct migration-regulating properties as they pertain to neural development, CNS injury, and gliomagenesis.
AuthorsDaniel J Silver, Jerry Silver
JournalCurrent opinion in neurobiology (Curr Opin Neurobiol) Vol. 27 Pg. 171-8 (Aug 2014) ISSN: 1873-6882 [Electronic] England
PMID24762654 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Chondroitin Sulfate Proteoglycans
Topics
  • Animals
  • Cell Movement (physiology)
  • Central Nervous System (cytology, growth & development, metabolism)
  • Central Nervous System Diseases (metabolism)
  • Chondroitin Sulfate Proteoglycans (physiology)
  • Humans
  • Models, Biological
  • Neoplasms (metabolism)
  • Neurons (metabolism, physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: