Curcumin ameliorates streptozotocin-induced heart injury in rats.

Abstract

Heart failure (HF) is one of diabetic complications. This work was designed to investigate the possible modulatory effect of curcumin against streptozotocin-induced diabetes and consequently HF in rats. Rats were divided into control, vehicle-treated, curcumin-treated, diabetic-untreated, diabetic curcumin-treated, and diabetic glibenclamide-treated groups. Animal treatment was started 5 days after induction of diabetes and extended for 6 weeks. Diabetic rats showed significant increase in serum glucose, triglycerides, total cholesterol, low-density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, nitric oxide, lactate dehydrogenase, cardiac malondialdehyde, plasma levels of interleukin-6, and tumor necrosis factor-alpha, and also showed marked decrease in serum high-density lipoprotein-cholesterol, cardiac reduced glutathione, and cardiac antioxidant enzymes (catalase, superoxide dismutase, and glutathione-S-transferase). However, curcumin or glibenclamide treatment significantly mitigated such changes. In conclusion, curcumin has a beneficial therapeutic effect in diabetes-induced HF, an effect that might be attributable to its antioxidant and suppressive activity on cytokines.

• Authors: Osama M Abo-Salem, Gamaleldin I Harisa, Tarek M Ali, El-Sayed M El-Sayed, Fatma M Abou-Elnour
• Journal: Journal of biochemical and molecular toxicology (J Biochem Mol Toxicol) Vol. 28 Issue 6 Pg. 263-70 (Jun 2014) ISSN: 1099-0461 [Electronic] United States
• PMID: 24760747 (Publication Type: Journal Article)
• Copyright: © 2014 Wiley Periodicals, Inc.

Chemical References

• Antioxidants
• Blood Glucose
• Inflammation Mediators
• Interleukin-6
• Tumor Necrosis Factor-alpha
• Nitric Oxide
• Streptozocin
• L-Lactate Dehydrogenase
• Glutathione
• Curcumin
• Glyburide

Topics

• Animals
• Antioxidants (pharmacology, therapeutic use)
• Blood Glucose
• Curcumin (pharmacology, therapeutic use)
• Diabetes Mellitus, Experimental (blood, chemically induced, complications)
• Glutathione (metabolism)
• Glyburide (pharmacology, therapeutic use)
• Heart Failure (blood, etiology, prevention & control)
• Inflammation Mediators (blood)
• Interleukin-6 (blood)
• L-Lactate Dehydrogenase (blood)
• Male
• Myocardium (metabolism, pathology)
• Nitric Oxide (blood)
• Organ Size (drug effects)
• Oxidative Stress
• Rats, Wistar
• Streptozocin
• Tumor Necrosis Factor-alpha (blood)