Melatonin in children with autism spectrum disorders: endogenous and pharmacokinetic profiles in relation to sleep.

Abstract

Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (C(max)) and time to peak concentration (T(max)) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin.

• Authors: Suzanne E Goldman, Karen W Adkins, M Wade Calcutt, Melissa D Carter, Robert L Goodpaster, Lily Wang, Yaping Shi, Helen J Burgess, David L Hachey, Beth A Malow
• Journal: Journal of autism and developmental disorders (J Autism Dev Disord) Vol. 44 Issue 10 Pg. 2525-35 (Oct 2014) ISSN: 1573-3432 [Electronic] United States
• PMID: 24752680 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Melatonin

Topics

• Child
• Child Development Disorders, Pervasive (blood, drug therapy)
• Child, Preschool
• Female
• Humans
• Male
• Melatonin (administration & dosage, blood)
• Polysomnography (methods)
• Sleep (drug effects, physiology)
• Sleep Initiation and Maintenance Disorders (blood, drug therapy)