[Expression and clinical significance of bone morphogenetic protein 6 in human breast cancer].

Abstract

OBJECTIVE:

To investigate the expression pattern and clinical significance of bone morphogenetic protein 6 (BMP6) in breast tissues.

METHODS:

The tumor and adjacent noncancerous tissues were harvested from 36 cases of breast cancer, the expression level of BMP6 mRNA of each sample was measured by quantitative RT-PCR. Immunohistochemistry study was used to examine BMP6 protein expression in 80 cases of breast cancer, then the relationship between the expression of BMP6 and relevant clinical and pathological parameters was analyzed.

RESULTS:

BMP6 mRNA expression in breast cancer was significantly reduced when compared with normal breast tissues (P< 0.01), BMP6 mRNA level in estrogen receptor-positive (ER) breast cancer was distinctly higher than that in ER breast cancer. The expression of BMP6 mRNA was correlated to tumor grade (P < 0.01). The expression level of BMP6 protein in breast cancer was associated to ER and PR status, histological grade and Ki-67 status (P < 0.05), but not correlated to age, tumor size, human epidermal factor receptor 2 (Her2) status and molecular subtypes of breast cancer (P > 0.05).

CONCLUSION:

The ectopic expression of BMP6 may play an important role in the development and progression of breast cancer.

• Authors: Geng Liu, Wen-Jing Lian, Hong-Ying Zhou, Ming-Jiang Bie
• Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 45 Issue 2 Pg. 249-53 (Mar 2014) ISSN: 1672-173X [Print] China
• PMID: 24749350 (Publication Type: Journal Article)

Chemical References

• BMP6 protein, human
• Bone Morphogenetic Protein 6
• Ki-67 Antigen
• RNA, Messenger
• Receptors, Estrogen
• Receptors, Progesterone

Topics

• Bone Morphogenetic Protein 6 (genetics, metabolism)
• Breast Neoplasms (genetics, metabolism)
• Female
• Humans
• Immunohistochemistry
• Ki-67 Antigen
• RNA, Messenger
• Receptors, Estrogen
• Receptors, Progesterone