[Postoperative analgesia with nefopam and non-steroidal anti-inflammatory drugs in patients after surgery for tumors of head and neck].

Abstract

MATERIALS AND METHODS:

83 adult patients included in the study were divided into two groups. Patients of the group-1 (n-49) had medium level of pain after cancer head and neck surgery. Patients of the group-2 (n-34) had severe pain. Three first postoperative days their post-operative multimodal analgesia started with tenoxycam 20 mg i.m. after induction of anesthesia, then every 24 hour (58 patients). 25 patients got ketoprofen 100 mg i.m. every 8-12 hours instead of tenoxycam. All patients had nefopam 30 mg i.m. 30 min prior the end of surgery procedure, and every 8 hours afterwards. 7 patients of the group-1 had more than 4 pain scores (day 1), 4 patients--at the day 2. They received tramadol or paracetamol additionally. 7 patients (group-2) also had up to 5 pain scores on the day 1, 5 patients had 4 pain scores on the day 2, and 3 patients 4 pain scores on the day 3. All that patients received additional analgesia with tramadol or trimeperidine once a day. 8.4% of patients suffered from adverse reactions (tachycardia, PONV and sweating).

CONCLUSION:

This method of multimodal postoperative analgesia is very simple and fairly efficient.

• Authors: V V Balandin, E S Gorobets
• Journal: Anesteziologiia i reanimatologiia (Anesteziol Reanimatol) 2014 Jan-Feb Issue 1 Pg. 40-3 ISSN: 0201-7563 [Print] Russia (Federation)
• PMID: 24749308 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Piroxicam
• Nefopam
• Ketoprofen
• tenoxicam

Topics

• Adult
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects, therapeutic use)
• Drug Administration Schedule
• Drug Therapy, Combination
• Head and Neck Neoplasms (surgery)
• Humans
• Ketoprofen (administration & dosage, adverse effects, therapeutic use)
• Middle Aged
• Nefopam (administration & dosage, adverse effects, therapeutic use)
• Pain Measurement
• Pain, Postoperative (prevention & control)
• Piroxicam (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Surgical Procedures, Operative (methods)
• Treatment Outcome
• Young Adult