Abstract | OBJECTIVE: The aim of this hypothesis-generating pilot study was to assess prospectively the objective and subjective effects of treatment with quetiapine XR on sleep during early recovery from alcohol dependence (AD). METHODS: Recovering subjects with AD and sleep disturbance complaints were treated with quetiapine XR (n = 10) or matching placebo pills (n = 10) for 8 weeks. Polysomnography was used to assess sleep objectively, and the Insomnia Severity Index and Pittsburgh Sleep Quality Index were used to measure subjective insomnia. Other assessment measures included the 10-minute psychomotor vigilance task (for neurobehavioral functioning), the time-line follow-back measure (for alcohol consumption), the Penn Alcohol Craving Scale (for alcohol craving), the Patient Health Questionnaire-9 item scale (for depressive symptoms), and the Beck Anxiety Inventory (for anxiety symptoms). RESULTS: Although there was no effect of quetiapine XR on sleep efficiency (time spent asleep/total recording time), there was a pre-to-post reduction in wake after sleep onset time (P = 0.03) and nonsignificant trends for increases in sleep onset latency ( SOL) and stage 2 sleep time. A time × drug interaction was seen for the subjective insomnia, such that quetiapine XR-treated subjects reported greater initial improvement in their subjective insomnia, but the difference was not sustained. There were no differences between treatment groups on other measures or medication compliance. CONCLUSION:
Quetiapine XR improves objective sleep continuity and transiently improves subjective insomnia early in recovery from AD.
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Authors | Subhajit Chakravorty, Alexandra L Hanlon, Samuel T Kuna, Richard J Ross, Kyle M Kampman, Lauren M Witte, Michael L Perlis, David W Oslin |
Journal | Journal of clinical psychopharmacology
(J Clin Psychopharmacol)
Vol. 34
Issue 3
Pg. 350-4
(Jun 2014)
ISSN: 1533-712X [Electronic] United States |
PMID | 24747978
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antipsychotic Agents
- Delayed-Action Preparations
- Dibenzothiazepines
- Quetiapine Fumarate
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Topics |
- Alcoholism
(rehabilitation)
- Antipsychotic Agents
(administration & dosage, therapeutic use)
- Craving
- Delayed-Action Preparations
- Dibenzothiazepines
(administration & dosage, therapeutic use)
- Double-Blind Method
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Pilot Projects
- Polysomnography
- Prospective Studies
- Psychomotor Performance
(drug effects)
- Quetiapine Fumarate
- Severity of Illness Index
- Sleep Initiation and Maintenance Disorders
(drug therapy, etiology)
- Surveys and Questionnaires
- Treatment Outcome
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